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The Best CBD Oils for Sleep and Insomnia (2020 Updated Review) As above, the best way to take CBD oil for sleep is to consume it 1-1.5 hours prior to going to bed. And when taking it, it’s best to take a somewhat higher dose, as low doses have been shown to have a more stimulating effect. A rule of thumb can be to take 60mg or more, but please adjust to your own needs, as everyone responds differently.